TDK Boulevard will be closed between Ga. Highway 74 and Dividend Drive from 9 p.m. Friday to 6 a.m. Monday to allow for maintenance work on the bridge.
The city is urging drivers to use Kelly Drive or Dividend Drive as a detour.
The $23,000 project will address a significant deterioration of the expansion joint on the bridge along with safety concerns, officials said last month.
The work will be performed by Massana Construction.